System and method for regulating a power conversion system. For example, a system controller includes a signal generator and one or more power-consumption components. The signal generator is configured to receive a feedback signal related to an output signal of the power conversion system, a current sensing signal and an input voltage, and to generate a control signal based on at least information associated with the feedback signal, the current sensing signal and the input voltage. The power-consumption components are configured to receive the control signal. The signal generator is further configured to determine whether the feedback signal is smaller than a feedback threshold for a first predetermined period of time, the current sensing signal is smaller than a current sensing threshold for a second predetermined period of time, and the input voltage is smaller than a first threshold for a third predetermined period of time in magnitude.