A method and apparatus reduces the likelihood of packet loss when an OFDMA transceiver and synchronous frame-based transceiver are operating on the same device. More specifically, a method protects reception of Bluetooth signals (such as reception of slave device signals) from co-existence interference caused by co-located OFDMA transceiver transmissions. The method receives a transmission-enable (TXE) signal indicating that the OFDMA transceiver is transmitting, determines an estimated transmission-enable (TXE′) signal indicating when the OFDMA transceiver is expected to be transmitting in the future, and sends the TXE′ signal to the Bluetooth transmitter to shut down Bluetooth transmissions when a transmission is expected to be sent from the OFDMA transceiver.