Connecting USB devices with USB hosts over a network supporting distributed initiations of USB connections over the network, including the following steps: Connecting non-collocated USB hosts with respective non-collocated USB host adaptors (USBHs), according to USB specification timings. Connecting non-collocated USB devices with respective non-collocated USB device adaptors (USBDs). Enabling the USBDs and the USBHs to communicate over the network and to discover the presence and capabilities of one another. Initiating, by the USBDs or the USBHs, via the network control plane, USB-over-network-data-plane connections between the USB devices and the USB hosts. And operating at least two of the USB-over-network-data-plane connections essentially simultaneously and without any common network node.