发明授权
- 专利标题: Oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles
- 专利标题(中): 口服剂型,包含至少一种生物活性剂,制剂辅助物质和可磁化颗粒
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申请号: US13390353申请日: 2010-08-30
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公开(公告)号: US09050256B2公开(公告)日: 2015-06-09
- 发明人: Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
- 申请人: Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
- 申请人地址: DE Darmstadt
- 专利权人: Evonik Röhm Gmbh
- 当前专利权人: Evonik Röhm Gmbh
- 当前专利权人地址: DE Darmstadt
- 代理机构: Oblon, McClelland, Maier & Neustadt, L.L.P.
- 优先权: DE102009029170 20090903
- 国际申请: PCT/EP2010/062641 WO 20100830
- 国际公布: WO2011/026808 WO 20110310
- 主分类号: A61B5/055
- IPC分类号: A61B5/055 ; A61K9/20 ; A61K9/28 ; A61K9/48 ; A61K9/50 ; A61K9/00
摘要:
The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
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