Invention Grant
US09051272B2 Process for the preparation of phenyl substituted 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-methoxy-[1-methyl-2 phenylethyl] amides
有权
苯基取代的3-二氟甲基-1-甲基-1H-吡唑-4-甲酸N-甲氧基 - [1-甲基-2-苯基乙基]酰胺的制备方法
- Patent Title: Process for the preparation of phenyl substituted 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-methoxy-[1-methyl-2 phenylethyl] amides
- Patent Title (中): 苯基取代的3-二氟甲基-1-甲基-1H-吡唑-4-甲酸N-甲氧基 - [1-甲基-2-苯基乙基]酰胺的制备方法
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Application No.: US14374547Application Date: 2013-02-26
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Publication No.: US09051272B2Publication Date: 2015-06-09
- Inventor: Daniel Stierli , Harald Walter , Michael Rommel , Reinhard Georg Hanreich , Martin Zeller , Thomas Vettiger , Tomas Smejkal
- Applicant: Syngenta Participations AG
- Applicant Address: CH Basel
- Assignee: Syngenta Participations AG
- Current Assignee: Syngenta Participations AG
- Current Assignee Address: CH Basel
- Agent R. Kody Jones
- Priority: EP12157354 20120228
- International Application: PCT/EP2013/053773 WO 20130226
- International Announcement: WO2013/127764 WO 20130906
- Main IPC: C07D231/12
- IPC: C07D231/12 ; C07D231/14
![Process for the preparation of phenyl substituted 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-methoxy-[1-methyl-2 phenylethyl] amides](/abs-image/US/2015/06/09/US09051272B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined in claim 1, which process comprises a) adding a compound of formula (II), in the presence of an inert organic solvent to a mixture comprising an organic nitrite of formula (III) (R4—O—N═O (III)), wherein R4 is C1-C8alkyl, a compound of formula (IV), and an inert organic solvent; b) reacting the resulting compound of formula (V), with H2N—O—CH3 to the compound of formula (VII), c) reducing the compound of formula (VII) to the compound of formula (VIII), d) and reacting the compound of formula VIII with a compound of formula (IX), in which R* is halogen, hydroxy or C1-6 alkoxy, to the compound of formula (I).
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