Invention Grant
- Patent Title: Aryl carboxamide derivatives as TTX-S blockers
- Patent Title (中): 芳酰胺衍生物作为TTX-S阻断剂
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Application No.: US13509442Application Date: 2010-11-16
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Publication No.: US09051296B2Publication Date: 2015-06-09
- Inventor: Tatsuya Yamagishi , Yoshimasa Arano , Mikio Morita , Tadashi Inoue
- Applicant: Tatsuya Yamagishi , Yoshimasa Arano , Mikio Morita , Tadashi Inoue
- Applicant Address: JP Aichi
- Assignee: RaQualia Pharma Inc.
- Current Assignee: RaQualia Pharma Inc.
- Current Assignee Address: JP Aichi
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- International Application: PCT/JP2010/006723 WO 20101116
- International Announcement: WO2011/058766 WO 20110519
- Main IPC: A61K31/435
- IPC: A61K31/435 ; A01N43/40 ; C07D221/04 ; C07D401/06 ; A61K31/44 ; A61K31/445 ; A61K31/4525 ; A61K31/4535 ; A61K31/454 ; A61K31/4545 ; A61K31/4709 ; A61K31/4725 ; A61K31/4745 ; A61K31/498 ; A61K31/4985 ; A61K31/506 ; A61K31/519 ; A61K31/5383 ; C07D211/46 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D405/06 ; C07D405/12 ; C07D405/14 ; C07D409/06 ; C07D413/06 ; C07D417/06 ; C07D417/10 ; C07D455/04 ; C07D471/04 ; C07D471/06 ; C07D487/04 ; C07D491/048 ; C07D495/04 ; C07D498/04 ; C07D513/04

Abstract:
The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar1 is phenyl; Ar2 is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO2—, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.
Public/Granted literature
- US20120232052A1 ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS Public/Granted day:2012-09-13
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