发明授权
US09051331B2 Substituted dihydro benzocycloalkyloxymethyl oxazolopyrimidinones, preparation and use thereof
有权
取代的二氢苯并环烷氧基甲基恶唑啉嘧啶酮，其制备和应用
- 专利标题： Substituted dihydro benzocycloalkyloxymethyl oxazolopyrimidinones, preparation and use thereof
- 专利标题（中）： 取代的二氢苯并环烷氧基甲基恶唑啉嘧啶酮，其制备和应用
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申请号： US13410723申请日： 2012-03-02
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公开(公告)号： US09051331B2公开(公告)日： 2015-06-09
- 发明人: Rosy Sher , Raymond Walter Kosley, Jr.
- 申请人： Rosy Sher , Raymond Walter Kosley, Jr.
- 申请人地址： FR Paris
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： FR Paris
- 优先权： FR1055806 20100716
- 主分类号： C07D491/048
- IPC分类号： C07D491/048 ; C07D498/04 ; A61K31/519 ; A61K31/522
摘要：
The present invention relates to a series of substituted dihydro benzocycloalkyl-oxymethyl oxazolopyrimidinones of formula (I): Wherein n, R1, R2, R3, R4, R5 and R6 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, cognition deficit disorders, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.
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