Image sensors include an array of image sensor pixels therein. This array of image sensor pixels includes a first focus detection pixel and at least a first color pixel. A switching network is provided, which is electrically coupled to the array. This switching network may be configured to generate a first mixed image signal by electronically mixing a focus detection signal generated by the first focus detection pixel with at least one color pixel signal generated by the at least a first color pixel. The first focus detection pixel can be a color-blind pixel, which may include a light-blocking shield mask therein.