发明授权
- 专利标题： Compositions and methods for treating cancer
- 专利标题（中）： 用于治疗癌症的组合物和方法
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申请号： US10556220申请日： 2004-05-07
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公开(公告)号： US09060993B2公开(公告)日： 2015-06-23
- 发明人: Craig B. Thompson , Daniel Bauer , Georgia Hatzivassiliou
- 申请人： Craig B. Thompson , Daniel Bauer , Georgia Hatzivassiliou
- 申请人地址： US PA Philadelphia
- 专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Pepper Hamilton LLP
- 国际申请： PCT/US2004/014263 WO 20040507
- 国际公布： WO2004/100885 WO 20041125
- 主分类号： A61K31/34
- IPC分类号： A61K31/34 ; A61K51/04
摘要：
Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
公开/授权文献
- US20070259956A1 Compositions and methods for treating cancer 公开/授权日：2007-11-08
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