Invention Grant
US09061068B2 Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding
有权
用于使用电荷相互作用和共价键的siRNA递送的聚合物纳米颗粒
- Patent Title: Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding
- Patent Title (中): 用于使用电荷相互作用和共价键的siRNA递送的聚合物纳米颗粒
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Application No.: US12905212Application Date: 2010-10-15
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Publication No.: US09061068B2Publication Date: 2015-06-23
- Inventor: Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
- Applicant: Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
- Applicant Address: KR
- Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR
- Agency: Ostrolenk Faber LLP
- Priority: KR10-2010-0089081 20100910
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A61K47/48 ; C12N15/11 ; C12N15/87
Abstract:
Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.
Public/Granted literature
- US20120065242A1 POLYMERIC NANO-PARTICLES FOR siRNA DELIVERY USING CHARGE INTERACTION AND COVALENT BONDING Public/Granted day:2012-03-15
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