发明授权
- 专利标题： Cyclohexyl-azetidinyl antagonists of CCR2
- 专利标题（中）： CCR2的环己基 - 氮杂环丁烷基拮抗剂
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申请号： US13947340申请日： 2013-07-22
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公开(公告)号： US09062048B2公开(公告)日： 2015-06-23
- 发明人: James C. Lanter , Thomas P. Markotan , Nalin Subasinghe , Zhihua Sui
- 申请人： Janssen Pharmaceutica NV
- 申请人地址： BE
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： BE
- 代理商 Mary A. Appollina
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; A61K31/47 ; C07D215/00 ; C07D471/04 ; A61K31/4709 ; A61K31/4725 ; A61K31/502 ; A61K31/517 ; A61K31/5377 ; A61K31/541 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D405/14 ; C07D413/14 ; C07D417/14
摘要：
The present invention comprises compounds of Formula I. wherein: R1, R2, R4, J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
公开/授权文献
- US20130310365A1 CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2 公开/授权日：2013-11-21
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