Invention Grant
- Patent Title: Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors
- Patent Title (中): 取代的咪唑并[2,1-A]异吲哚作为PDE10抑制剂
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Application No.: US14309423Application Date: 2014-06-19
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Publication No.: US09062060B2Publication Date: 2015-06-23
- Inventor: Jan Kehler , Jacob Nielsen , Mauro Marigo , John Paul Kilburn , Morten Langgård
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agent Mary Catherine Di Nunzio
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D471/04 ; C07D487/04 ; C07D519/00 ; A61K31/437 ; A61K31/4985 ; A61K45/06
![Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors](/abs-image/US/2015/06/23/US09062060B2/abs.jpg.150x150.jpg)
Abstract:
This invention is directed to compounds with the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
Public/Granted literature
- US20140357639A1 Imidazole derivatives as PDE10 enzyme inhibitors Public/Granted day:2014-12-04
Information query