发明授权
US09062094B2 Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
有权
用于脂肪族胺的药物的基于二肽的前药接头
- 专利标题： Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
- 专利标题（中）： 用于脂肪族胺的药物的基于二肽的前药接头
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申请号： US13574092申请日： 2011-01-21
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公开(公告)号： US09062094B2公开(公告)日： 2015-06-23
- 发明人: Harald Rau , Torben Lessmann
- 申请人： Harald Rau , Torben Lessmann
- 申请人地址： DK Hellerup
- 专利权人： Ascendis Pharma AS
- 当前专利权人： Ascendis Pharma AS
- 当前专利权人地址： DK Hellerup
- 代理机构： Frommer Lawrence & Haug LLP
- 优先权： EP10151465 20100122
- 国际申请： PCT/EP2011/050821 WO 20110121
- 国际公布： WO2011/089216 WO 20110728
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K47/00 ; C07K1/13 ; A61K47/48 ; C07K1/107
摘要：
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aliphatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
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