发明授权
US09066870B2 Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles
有权
用于药物递送的方法包括折叠和折叠蛋白质和肽纳米颗粒
- 专利标题： Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles
- 专利标题（中）： 用于药物递送的方法包括折叠和折叠蛋白质和肽纳米颗粒
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申请号： US12851600申请日： 2010-08-06
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公开(公告)号： US09066870B2公开(公告)日： 2015-06-30
- 发明人: Yiqiao Hu , Jinhui Wu , Dawei Ding , Guangming Gong , Xiaolei Tang , Chunhui Tong , Yan Zhu , Shaoling Li
- 申请人： Yiqiao Hu , Jinhui Wu , Dawei Ding , Guangming Gong , Xiaolei Tang , Chunhui Tong , Yan Zhu , Shaoling Li
- 申请人地址： CN Nanjing CN Nanjing
- 专利权人： Nanjing University,Nanjing Effect Pharm Drug Development Corporation
- 当前专利权人： Nanjing University,Nanjing Effect Pharm Drug Development Corporation
- 当前专利权人地址： CN Nanjing CN Nanjing
- 代理机构： Michael Best & Friedrich LLP
- 代理商 Lisa V. Mueller
- 主分类号： A61K9/16
- IPC分类号： A61K9/16 ; A61K9/28 ; B01J13/00 ; B05D3/00 ; A61K9/19 ; A61K9/51
摘要：
The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protein, and subsequently refolding or assembling the protein to produce a pharmacologically active agent encased within a protein nanoparticle.
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