发明授权
US09067891B2 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mGluR2-receptors
有权
1,4-二取代的3-氰基 - 吡啶酮衍生物及其作为mGluR2受体的正变构调节剂的用途
- 专利标题: 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mGluR2-receptors
- 专利标题(中): 1,4-二取代的3-氰基 - 吡啶酮衍生物及其作为mGluR2受体的正变构调节剂的用途
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申请号: US13610000申请日: 2012-09-11
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公开(公告)号: US09067891B2公开(公告)日: 2015-06-30
- 发明人: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James Macdonald , Guillaume Albert Jacques Duvey , Robert Johannes Lutjens
- 申请人: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James Macdonald , Guillaume Albert Jacques Duvey , Robert Johannes Lutjens
- 申请人地址: US NJ Titusville CH Geneva
- 专利权人: JANSSEN PHARMACEUTICALS, INC.,ADDEX PHARMA SA
- 当前专利权人: JANSSEN PHARMACEUTICALS, INC.,ADDEX PHARMA SA
- 当前专利权人地址: US NJ Titusville CH Geneva
- 代理机构: Baker & Hostetler LLP
- 优先权: EP07103654 20070307; WOPCT/EP2007/052442 20070315; EP07116402 20070914
- 主分类号: A61K31/443
- IPC分类号: A61K31/443 ; C07D401/04 ; C07D213/85 ; A61K31/198 ; A61K31/444
摘要:
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.