发明授权
US09067924B2 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
有权
1,4硫辛啶/砜作为BACE1和/或BACE2抑制剂
- 专利标题： 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
- 专利标题（中）： 1,4硫辛啶/砜作为BACE1和/或BACE2抑制剂
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申请号： US13405398申请日： 2012-02-27
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公开(公告)号： US09067924B2公开(公告)日： 2015-06-30
- 发明人: Hans Hilpert , Mark Rogers-Evans , Didier Rombach
- 申请人： Hans Hilpert , Mark Rogers-Evans , Didier Rombach
- 申请人地址： US NJ Nutley
- 专利权人： HOFFMANN-LA ROCHE INC.
- 当前专利权人： HOFFMANN-LA ROCHE INC.
- 当前专利权人地址： US NJ Nutley
- 优先权： EP11156976 20110304
- 主分类号： A61K31/554
- IPC分类号： A61K31/554 ; C07D417/10 ; C07D513/04 ; C07D417/12
摘要：
The present invention relates to 1,4 Thiazepines/Sulfones of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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