Invention Grant
US09072748B2 BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
有权
用于治疗癌症和免疫疾病的BCL-2选择性细胞凋亡诱导剂
- Patent Title: BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
- Patent Title (中): 用于治疗癌症和免疫疾病的BCL-2选择性细胞凋亡诱导剂
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Application No.: US14058164Application Date: 2013-10-18
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Publication No.: US09072748B2Publication Date: 2015-07-07
- Inventor: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: Jones Day
- Main IPC: C07D405/06
- IPC: C07D405/06 ; C07D413/06 ; C07D487/04 ; C07D241/04 ; C07D401/06 ; A61K31/5377 ; C07D209/32 ; C07D211/96 ; C07D213/64 ; C07D215/20 ; C07D217/16 ; C07D231/56 ; C07D235/26 ; C07D249/04 ; C07D295/125 ; C07D295/14 ; C07D309/14 ; C07D401/12 ; C07D405/12 ; C07D405/14 ; C07D417/12 ; C07D471/04 ; A61K31/407 ; A61K31/495 ; A61K31/496 ; A61K31/501 ; A61K45/06 ; C07D403/06
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Public/Granted literature
- US20140057890A1 BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES Public/Granted day:2014-02-27
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