发明授权
US09073975B2 Cyclic peptides, their preparation and their use as inhibitors of the platelet adhesion
有权
循环肽，它们的制备及其作为血小板粘附抑制剂的用途
- 专利标题： Cyclic peptides, their preparation and their use as inhibitors of the platelet adhesion
- 专利标题（中）： 循环肽，它们的制备及其作为血小板粘附抑制剂的用途
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申请号： US13818444申请日： 2011-07-27
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公开(公告)号： US09073975B2公开(公告)日： 2015-07-07
- 发明人: Otmar Klingler , Horst Blum , Andreas Lindenschmidt , Hans Matter
- 申请人： Otmar Klingler , Horst Blum , Andreas Lindenschmidt , Hans Matter
- 申请人地址： FR Paris
- 专利权人： SANOFI
- 当前专利权人： SANOFI
- 当前专利权人地址： FR Paris
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 代理商 Sabine Venne-Dunker
- 优先权： EP10305842 20100729
- 国际申请： PCT/EP2011/062917 WO 20110727
- 国际公布： WO2012/013709 WO 20120202
- 主分类号： C07K7/64
- IPC分类号： C07K7/64 ; C07K7/06 ; C07K7/56 ; A61K38/00
摘要：
The present invention relates to compounds of the Formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, X1, X2, X3 and X4 have the meanings indicated in the claims, and which are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb), and are suitable, for example, for the therapy and prophylaxis of athero-thrombotic diseases. The invention furthermore relates to processes for the preparation of compounds of the Formula (I), their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them.