A method for the co-simulation of two or more interacting mathematical models in which each model has at least one input port and one output port for inputting and outputting values of parameters in a predefined parameter protocol. The unit of measurement is identified for each parameter in the model and a scaling factor is then generated to equalize the units of measurement for each parameter in each model. The parameter protocol for each port is then determined and a virtual bus with unique locations is configured for each parameter in the models. The parameters from the models are then configured as a function of the parameter protocol so that the same parameters from different models are associated with the same location in the virtual bus.