Methods for preventing coexistence interference between a Bluetooth Low Energy (BLE) radio and a collocated LTE radio are provided. In a first solution, the BLE radio adds padding bytes to BLE packets such that the total packet length falls in a specific range to prevent coexistence interference. In a second solution, the BLE radio limits the total BLE packet length to a predefined length to prevent coexistence interference. In a third solution, the data rate for transmitting the BLE packets is higher than a predefined rate to prevent coexistence interference. In a fourth solution, the BLE radio dynamically adjusts the time inter-frame-spacing (T_IFS) value to prevent coexistence interference with the collocated LTE radio.