A method for manufacturing a waterproof and vapor-permeable shoe, consisting in preparing a semimanufactured component of an upper for a shoe, such that it can be arranged spread out on a flat surface or on two mutually opposite surfaces, then arranging on the inner part of the semimanufactured component of an upper a waterproof and vapor-permeable membrane, then preparing means for adhesive bonding between the semimanufactured component of an upper and the membrane so as to not inhibit the vapor-permeability of the assembly. One or more shapes, capable of shaping themselves complementarily with respect to the different thicknesses of the stitched seams and of the superimposed parts which constitute the outer surface of the semimanufactured component of an upper are prepared, and the membrane is coupled to the semimanufactured component of an upper, with the outer part of the component arranged so that the outer surface rests on the shape.