A mobile x-ray imaging unit with an integrated x-ray shield is disclosed. The mobile x-ray imaging unit includes a base, a column structure extending upwardly from the base, a horizontal arm mounted on the column structure, and an x-ray source positioned on the horizontal arm, with the x-ray source configured to generate x-ray radiation for acquisition of an x-ray image. The mobile x-ray imaging unit also includes an x-ray shield extending upwardly from the base on a side of the column structure opposite the x-ray source that is configured to attenuate x-ray radiation generated by the x-ray source, wherein at least a portion of the x-ray shield is formed of an optically transparent material and wherein the x-ray shield is sized so as to provide x-ray shielding to an operator when the operator is in a standing position.