发明授权
- 专利标题： Method for treating ocular cancer
- 专利标题（中）： 治疗眼癌的方法
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申请号： US14097746申请日： 2013-12-05
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公开(公告)号： US09078895B2公开(公告)日： 2015-07-14
- 发明人: Michael A. Dyer , Jean-Christophe Marine , Aart Gerrit Jochemsen
- 申请人： St. Jude Children's Research Hospital , Flanders Interuniversity Institute for Biotechnology VIB , Universiteit Gent , Leiden University Medical Center
- 申请人地址： US TN Memphis BE Ghent BE Ghent NL Leiden
- 专利权人： St. Jude Children's Research Hospital,Flanders Interuniversity Institute for Biotechnology,Universiteit Gent,Leiden University Medical Center
- 当前专利权人： St. Jude Children's Research Hospital,Flanders Interuniversity Institute for Biotechnology,Universiteit Gent,Leiden University Medical Center
- 当前专利权人地址： US TN Memphis BE Ghent BE Ghent NL Leiden
- 代理机构： Licata & Tyrrell P.C.
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/00 ; G01N33/574 ; A61K31/473
摘要：
It has now been found that the p53 pathway is inactivated in ocular cancers such as retinoblastoma. As such, the present invention is a method for inducing ocular cancer cell death using a p53 activator. In particular embodiments, the p53 activator blocks the interaction between DM2 or DMX and p53. As the p53 activator induces ocular cancer cell death, a method for preventing or treating ocular cancer is also provided.
公开/授权文献
- US20140121218A1 METHOD FOR TREATING OCULAR CANCER 公开/授权日：2014-05-01
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