发明授权
US09078912B2 Asthma diagnosis using the neuropilin-1 gene, and method for screening for a therapeutic agent for asthma
有权
使用神经蛋白-1基因进行哮喘诊断，以及筛选哮喘治疗剂的方法
- 专利标题： Asthma diagnosis using the neuropilin-1 gene, and method for screening for a therapeutic agent for asthma
- 专利标题（中）： 使用神经蛋白-1基因进行哮喘诊断，以及筛选哮喘治疗剂的方法
-
申请号： US13807829申请日： 2011-07-01
-
公开(公告)号： US09078912B2公开(公告)日： 2015-07-14
- 发明人: Hyeong Kyu Lee , Kyung Seop Ahn , Yoosik Yoon , Byoung Whui Choi , Ok-Kyoung Kwon , Semi Kim , Hui Seong Kim , Sei Ryang Oh , Ji Eun Yuk , Ha Young Jang
- 申请人： Hyeong Kyu Lee , Kyung Seop Ahn , Yoosik Yoon , Byoung Whui Choi , Ok-Kyoung Kwon , Semi Kim , Hui Seong Kim , Sei Ryang Oh , Ji Eun Yuk , Ha Young Jang
- 申请人地址： KR Daejeon
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Lucas & Mercanti, LLP
- 优先权： KR10-2010-0063905 20100702
- 国际申请： PCT/KR2011/004864 WO 20110701
- 国际公布： WO2012/002775 WO 20120105
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12N15/11 ; A61K31/7088 ; C07K14/71 ; C12Q1/68
摘要：
The present invention relates to a kit for the diagnosis or screening of asthma comprising neuropilin (NRP) gene, and to a method for screening a therapeutic agent for asthma using the same. More precisely, the present invention confirmed that NRP1 expression was increased in asthma patients and by D. pteronissinus extract. Based on the confirmation, the inventors confirmed that NRP1 could be effectively used as a target for the development of a therapeutic agent for asthma since the suppression of NRP1 expression resulted in the decrease of mRNA, protein, enzyme activity, and promoter activity of MMP-9 in relation to asthma.
公开/授权文献
信息查询
