Invention Grant
US09078912B2 Asthma diagnosis using the neuropilin-1 gene, and method for screening for a therapeutic agent for asthma
有权
使用神经蛋白-1基因进行哮喘诊断，以及筛选哮喘治疗剂的方法
- Patent Title: Asthma diagnosis using the neuropilin-1 gene, and method for screening for a therapeutic agent for asthma
- Patent Title (中): 使用神经蛋白-1基因进行哮喘诊断，以及筛选哮喘治疗剂的方法
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Application No.: US13807829Application Date: 2011-07-01
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Publication No.: US09078912B2Publication Date: 2015-07-14
- Inventor: Hyeong Kyu Lee , Kyung Seop Ahn , Yoosik Yoon , Byoung Whui Choi , Ok-Kyoung Kwon , Semi Kim , Hui Seong Kim , Sei Ryang Oh , Ji Eun Yuk , Ha Young Jang
- Applicant: Hyeong Kyu Lee , Kyung Seop Ahn , Yoosik Yoon , Byoung Whui Choi , Ok-Kyoung Kwon , Semi Kim , Hui Seong Kim , Sei Ryang Oh , Ji Eun Yuk , Ha Young Jang
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2010-0063905 20100702
- International Application: PCT/KR2011/004864 WO 20110701
- International Announcement: WO2012/002775 WO 20120105
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12N15/11 ; A61K31/7088 ; C07K14/71 ; C12Q1/68
Abstract:
The present invention relates to a kit for the diagnosis or screening of asthma comprising neuropilin (NRP) gene, and to a method for screening a therapeutic agent for asthma using the same. More precisely, the present invention confirmed that NRP1 expression was increased in asthma patients and by D. pteronissinus extract. Based on the confirmation, the inventors confirmed that NRP1 could be effectively used as a target for the development of a therapeutic agent for asthma since the suppression of NRP1 expression resulted in the decrease of mRNA, protein, enzyme activity, and promoter activity of MMP-9 in relation to asthma.
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