发明授权
- 专利标题: Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same
- 专利标题(中): 药学可接受的增溶组合物和含有它的药物剂型
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申请号: US12305870申请日: 2007-07-17
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公开(公告)号: US09078921B2公开(公告)日: 2015-07-14
- 发明人: Jörg Rosenberg , Jörg Breitenbach , Kennan Marsh , Bernd Liepold , Christoph Schmidt , Ute Lander
- 申请人: Jörg Rosenberg , Jörg Breitenbach , Kennan Marsh , Bernd Liepold , Christoph Schmidt , Ute Lander
- 申请人地址: DE Wiesbaden
- 专利权人: Abbvie Deutschland GmbH & Co KG
- 当前专利权人: Abbvie Deutschland GmbH & Co KG
- 当前专利权人地址: DE Wiesbaden
- 代理机构: Saul Ewing LLP
- 代理商 Peter C. Lauro, Esq.
- 优先权: EP06015076 20060719
- 国际申请: PCT/EP2007/057392 WO 20070717
- 国际公布: WO2008/009689 WO 20080124
- 主分类号: A61P31/18
- IPC分类号: A61P31/18 ; A61K47/34 ; A61K9/48 ; A61K31/513 ; A61K47/22 ; A61K9/14 ; A61K9/20 ; A61K31/427 ; A61K47/14
摘要:
A pharmaceutically acceptable solubilizing composition comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono- and diester is disclosed. The solubilizing composition is useful in the manufacture of a pharmaceutical dosage form which comprises a melt-processed mixture of at least one active ingredient, at least one pharmaceutically acceptable polymer. The active ingredient(s) may be inhibitors of HIV protease. The solubilizing composition enhances the bioavailability of the active ingredient after oral intake.