发明授权
- 专利标题: HIV protease inhibitors
- 专利标题(中): HIV蛋白酶抑制剂
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申请号: US13882267申请日: 2011-10-27
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公开(公告)号: US09079834B2公开(公告)日: 2015-07-14
- 发明人: Michael John Boyd , Carmela Molinaro , Amelie Roy , Vouy-Linh Truong
- 申请人: Michael John Boyd , Carmela Molinaro , Amelie Roy , Vouy-Linh Truong
- 申请人地址: CA Kirkland, Quebec
- 专利权人: Merck Canada Inc.
- 当前专利权人: Merck Canada Inc.
- 当前专利权人地址: CA Kirkland, Quebec
- 代理商 Carol S. Quagliato; Laura M. Ginkel
- 国际申请: PCT/CA2011/001202 WO 20111027
- 国际公布: WO2012/055031 WO 20120503
- 主分类号: C07C311/42
- IPC分类号: C07C311/42 ; C07D277/82 ; C07D417/12 ; C07C311/39 ; C07C311/29 ; C07C311/41 ; C07D277/62 ; C07D413/12
摘要:
Compounds of Formula I are disclosed wherein R1, R2, R3A, R3B, R4A, R4B, R5A, R5B, R6A, R6B, R7, R8 and R9 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
公开/授权文献
- US20140018325A1 HIV PROTEASE INHIBITORS 公开/授权日:2014-01-16
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