发明授权
US09079863B2 Crystalline forms for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, pharmaceutical preparations containing the same and method for the production of said forms
有权
5-氨基-2,3-二氢酞嗪-1,4-二酮钠盐的结晶形式，含有该氨基酸的药物制剂和生产所述形式的方法
- 专利标题： Crystalline forms for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, pharmaceutical preparations containing the same and method for the production of said forms
- 专利标题（中）： 5-氨基-2,3-二氢酞嗪-1,4-二酮钠盐的结晶形式，含有该氨基酸的药物制剂和生产所述形式的方法
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申请号： US14247626申请日： 2014-04-08
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公开(公告)号： US09079863B2公开(公告)日： 2015-07-14
- 发明人: Josef Breu , Wolfgang Brysch , Astrid Kaiser , Beate Ludescher , Gerrit Maass , Thomas Martin , Wolfgang Milius , Michael Niedermaier
- 申请人： METRIOPHARM AG
- 申请人地址： CH Zurich
- 专利权人： MetrioPharm AG
- 当前专利权人： MetrioPharm AG
- 当前专利权人地址： CH Zurich
- 代理机构： Millen, White, Zelano, Branigan, P.C.
- 优先权： EP10002067 20100301; EP10075744 20101125
- 主分类号： C07D237/30
- IPC分类号： C07D237/30 ; A61K31/50 ; A01N43/58 ; C07D237/32
摘要：
The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.
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