Invention Grant
- Patent Title: Spiro-oxindole MDM2 antagonists
- Patent Title (中): 螺羟吲哚MDM2拮抗剂
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Application No.: US14485054Application Date: 2014-09-12
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Publication No.: US09079913B2Publication Date: 2015-07-14
- Inventor: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones, S.C.
- Main IPC: C07D487/10
- IPC: C07D487/10 ; A61K31/407 ; A61K31/454 ; A61K31/496 ; A61K31/5377 ; A61K31/675 ; A61K45/06 ; C07D491/107 ; C07D495/10 ; C07D471/20 ; C07F9/6561
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
Public/Granted literature
- US20140378680A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS Public/Granted day:2014-12-25
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