发明授权
- 专利标题： Chemical preparation of polyubiquitin chains
- 专利标题（中）： 多聚遍在蛋白链的化学制备
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申请号： US13578015申请日： 2011-02-09
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公开(公告)号： US09079966B2公开(公告)日： 2015-07-14
- 发明人: Ashraf Brik , Mahmood Haj-Yahya , Ajish Kumar , Leslie Erlich , Liat Spasser
- 申请人： Ashraf Brik , Mahmood Haj-Yahya , Ajish Kumar , Leslie Erlich , Liat Spasser
- 申请人地址： IL Beer-Sheva
- 专利权人： BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
- 当前专利权人： BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
- 当前专利权人地址： IL Beer-Sheva
- 代理机构： Browdy and Neimark, PLLC
- 国际申请： PCT/IL2011/000137 WO 20110209
- 国际公布： WO2011/098998 WO 20110818
- 主分类号： C07K1/00
- IPC分类号： C07K1/00 ; C07K1/107 ; C07K14/00 ; C07K14/435 ; C07K14/47
摘要：
The present invention discloses a process for the preparation of a Poly-ubiquitin chain, this process comprising ligating a Ubiquitin thioester Ubm-SR with a Ubiquitin Ubq. Further are disclosed poly-ubiquitin chains prepared according to this process, in particular poly-ubiquitin chains containing at least one unnatural amino acid.
公开/授权文献
- US20130060003A1 CHEMICAL PREPARATION OF POLYUBIQUITIN CHAINS 公开/授权日：2013-03-07
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