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US09079968B2 Establishment of motif comprising acidic amino acid, capable of stabilizing protein in cells, and applicable to protein therapy, control of differentiation/undifferentiation of cell and antibody therapy 有权
建立包含酸性氨基酸，能够稳定细胞中蛋白质，适用于蛋白质治疗，控制细胞分化/未分化和抗体治疗的基序

  • 专利标题： Establishment of motif comprising acidic amino acid, capable of stabilizing protein in cells, and applicable to protein therapy, control of differentiation/undifferentiation of cell and antibody therapy
  • 专利标题（中）： 建立包含酸性氨基酸，能够稳定细胞中蛋白质，适用于蛋白质治疗，控制细胞分化/未分化和抗体治疗的基序
  • 申请号： US13321381
    申请日： 2009-11-20
  • 公开(公告)号： US09079968B2
    公开(公告)日： 2015-07-14
  • 发明人: Shigemasa Hanazawa , Yoshikazu Masuhiro
  • 申请人： Shigemasa Hanazawa , Yoshikazu Masuhiro
  • 申请人地址： JP Tokyo
  • 专利权人： NIHON UNIVERSITY
  • 当前专利权人： NIHON UNIVERSITY
  • 当前专利权人地址： JP Tokyo
  • 优先权： JP2009-122552 20090520
  • 国际申请： PCT/JP2009/070081 WO 20091120
  • 国际公布： WO2010/134226 WO 20101125
  • 主分类号： C07K14/47
  • IPC分类号： C07K14/47
Establishment of motif comprising acidic amino acid, capable of stabilizing protein in cells, and applicable to protein therapy, control of differentiation/undifferentiation of cell and antibody therapy
摘要：
A motif is searched which can inhibit the proteolysis of a protein that has been administered to a cell or an individual. Thus, disclosed is a method for designing/producing a protein having resistance to proteolysis. Specifically disclosed is a motif capable of inhibiting proteolysis, which comprises an amino acid region lying between the 396th position and the 410th position from the C-terminal of DP-1.
摘要（中）：

搜索可抑制已经施用于细胞或个体的蛋白质的蛋白水解的图案。 因此，公开了设计/制造具有蛋白水解抗性的蛋白质的方法。 具体公开的是能够抑制蛋白水解的基序，其包含位于DP-1的C-末端的第396位和410位之间的氨基酸区。

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