发明授权
- 专利标题： HBV treatment
- 专利标题（中）： HBV治疗
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申请号： US13882124申请日： 2011-10-27
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公开(公告)号： US09080174B2公开(公告)日： 2015-07-14
- 发明人: Michael Wayne Graham , Peter French , York YuanYuan Zhu , Yixiang Lu , TieJun Li , Yuncheng Sun , XiaoJun Tang , Li Shan
- 申请人： Michael Wayne Graham , Peter French , York YuanYuan Zhu , Yixiang Lu , TieJun Li , Yuncheng Sun , XiaoJun Tang , Li Shan
- 申请人地址： AU Balmain, New South Wales
- 专利权人： BENITEC BIOPHARMA LIMITED
- 当前专利权人： BENITEC BIOPHARMA LIMITED
- 当前专利权人地址： AU Balmain, New South Wales
- 代理机构： Knobbe, Martens, Olson & Bear, LLP
- 优先权： CN201010521948 20101028; CN201010521962 20101028; CN201010521972 20101028; CN201010521975 20101028; CN201010521990 20101028; CN201010522003 20101028; CN201010522005 20101028
- 国际申请： PCT/CN2011/081386 WO 20111027
- 国际公布： WO2012/055362 WO 20120503
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/113
摘要：
RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.
公开/授权文献
- US20130296401A1 HBV TREATMENT 公开/授权日：2013-11-07
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