A capacitive touch panel controller has a memory and multiple driving signal output units. At least one transistor of each driving signal output unit and multiple transistors of the memory are fabricated by an identical semiconductor fabrication process so that the gate oxide layers of the transistors of the driving signal output unit and the memory are identical in thickness. As the transistor of each driving signal output unit and those of the memory are fabricated by a same high-voltage semiconductor fabrication process, the transistor of each driving signal output unit can be fabricated to provide a capacitive touch panel controller having high-voltage driving capability without using any high-voltage fabrication process and increasing the production cost. Due to the high-voltage driving, the SNR and anti-interference capability can be increased.