Operating M-PHY communications protocol over a Serial Advanced Technology Attachment SATA-based interface and related devices, systems, and methods are disclosed. In one embodiment, the system operates the M-PHY communications over a SATA interface. Related cables, connectors, systems, and methods are also disclosed. In particular, embodiments of the present disclosure take the M-PHY standard compliant signals and direct them through a SATA compliant connector (and optionally cable) so as to allow two M-PHY standard compliant devices having SATA connectors to communicate.