The invention relates to rehabilitation systems and methods for providing therapy to individuals who have suffered a stroke or other neurological insult. A rehabilitation system may comprise a depth sensing camera positioned to view a workspace into which a patient's hands may be located, a display system viewable by the patient, and an electronic computer executing a stored program to display a representation of a virtual space holding at least one virtual object, display a representation of at least one hand of the patient, and monitor a virtual manipulation of the virtual object by the patient's hand. Other embodiments may include virtual reality goggles, head motion tracking, various exercises and of varying difficulty, tracking metrics and recording for subsequent playback.