Collaborative musical performance and/or composition may be facilitated in virtual spaces. A song selection and/or a first instrument selection associated with a first avatar may be received. A representation may be provided in the virtual space of the first avatar playing a first track of the song using the first instrument, which may correspond to a component of the song associated with the first instrument. A second avatar may be prompted to select a second instrument responsive to the second avatar being positioned within an interaction region associated with the first avatar. A representation may be provided in the virtual space of the first avatar playing a first track of the first song using the first instrument and the second avatar playing a second track of the first song using the second instrument. The second track may correspond to a component of the first song associated with the second instrument.