发明授权
US09095536B2 Aβ immunogenic peptide carrier conjugates and methods of producing same
有权
A&bgr 免疫原性肽载体缀合物及其生产方法
- 专利标题: Aβ immunogenic peptide carrier conjugates and methods of producing same
- 专利标题(中): A&bgr 免疫原性肽载体缀合物及其生产方法
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申请号: US11841919申请日: 2007-08-20
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公开(公告)号: US09095536B2公开(公告)日: 2015-08-04
- 发明人: Rasappa G. Arumugham , A. Krishna Prasad , Michael Hagen
- 申请人: Rasappa G. Arumugham , A. Krishna Prasad , Michael Hagen
- 申请人地址: IE County Cork US NY New York
- 专利权人: Janssen Sciences Ireland UC,Wyeth LLC
- 当前专利权人: Janssen Sciences Ireland UC,Wyeth LLC
- 当前专利权人地址: IE County Cork US NY New York
- 代理机构: Alston & Bird LLP
- 主分类号: A61K38/04
- IPC分类号: A61K38/04 ; C07K7/06 ; C07K17/00 ; G01N33/532 ; A61K39/00 ; A61K47/48
摘要:
The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
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