发明授权
US09095596B2 Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
有权
神经变性疾病的治疗,记忆增强的病因,以及用于筛选化合物的测定
- 专利标题: Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
- 专利标题(中): 神经变性疾病的治疗,记忆增强的病因,以及用于筛选化合物的测定
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申请号: US13501934申请日: 2010-10-14
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公开(公告)号: US09095596B2公开(公告)日: 2015-08-04
- 发明人: Maurizio Grimaldi , Judith Varady Hobrath , Subramaniam Ananthan , Joseph A. Maddry
- 申请人: Maurizio Grimaldi , Judith Varady Hobrath , Subramaniam Ananthan , Joseph A. Maddry
- 申请人地址: US AL Birmingham
- 专利权人: Southern Research Institute
- 当前专利权人: Southern Research Institute
- 当前专利权人地址: US AL Birmingham
- 代理机构: Novak Druce Connolly Bove + Quigg LLP
- 国际申请: PCT/US2010/052624 WO 20101014
- 国际公布: WO2011/047129 WO 20110421
- 主分类号: A61K31/675
- IPC分类号: A61K31/675 ; A61K31/427 ; A61K31/4402 ; C07D417/02 ; C07D417/14 ; C07D277/38 ; C07D277/20 ; C07D213/72
摘要:
Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.