Invention Grant
- Patent Title: Analytical method for fab and fab′ molecules
- Patent Title (中): 晶圆和晶圆分子的分析方法
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Application No.: US14275055Application Date: 2014-05-12
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Publication No.: US09096887B2Publication Date: 2015-08-04
- Inventor: Bryan John Smith , Helen Marie Kirke
- Applicant: UCB PHARMA, S.A.
- Applicant Address: BE Brussels
- Assignee: UCB PHARMA, S.A.
- Current Assignee: UCB PHARMA, S.A.
- Current Assignee Address: BE Brussels
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Main IPC: C12Q1/37
- IPC: C12Q1/37 ; G01N33/68
Abstract:
A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab or Fab′ to provide isolated Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG.
Public/Granted literature
- US20140242625A1 ANALYTICAL METHOD FOR FAB AND FAB' MOLECULES Public/Granted day:2014-08-28
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