发明授权
- 专利标题: 2′ and 5′ modified monomers and oligonucleotides
- 专利标题(中): 2'和5'修饰的单体和寡核苷酸
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申请号: US13638891申请日: 2011-03-31
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公开(公告)号: US09102938B2公开(公告)日: 2015-08-11
- 发明人: Kallanthottathil G. Rajeev , Muthiah Manoharan , Eric E. Swayze , Thazha P. Prakash
- 申请人: Kallanthottathil G. Rajeev , Muthiah Manoharan , Eric E. Swayze , Thazha P. Prakash
- 申请人地址: US MA Cambridge
- 专利权人: ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人: ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址: US MA Cambridge
- 代理机构: LeClair Ryan
- 代理商 Jeffrey N. Townes
- 国际申请: PCT/US2011/030695 WO 20110331
- 国际公布: WO2011/123621 WO 20111006
- 主分类号: C07H21/02
- IPC分类号: C07H21/02 ; C12N15/113 ; C07H19/067 ; A61K48/00 ; C07H19/06 ; C07H19/16
摘要:
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2):Formula (1) and Formula (2). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
公开/授权文献
- US20130203836A1 2' AND 5' MODIFIED MONOMERS AND OLIGONUCLEOTIDES 公开/授权日:2013-08-08