Systems, methods, protocols and apparatus for information exchange and synchronization using DTMF signaling over telephone communication channels are provided. Information is packetized and converted from one format, e.g., ASCII formatted data, to another format, e.g., BCD formatted data. The information is wrapped in one or more packets by a sending apparatus, each packet including one or more headers, such as a Name and Length field that identify the information being exchanged and the amount of data included in the packet payload/value field. The data in the packets are converted from BCD to DTMF signals and are transmitted over a telephone communication line to a receiving apparatus. The receiving apparatus converts the DTMF signals back to BCD formatted data and processes the packets to obtain the information contained therein.