An exemplary method includes an interactive media program guide system 1) displaying a user-scrollable view of a section of a paginated column of an interactive media program guide that includes a two-dimensional matrix grid of cells representing a plurality of media program listings, 2) detecting a user selection of a cell included in the matrix grid of cells and the user-scrollable view, the cell representing a media program listing included in the plurality of media program listings, and, 3) in response to the user selection of the cell, expanding the cell in-place within the paginated column of the interactive media program guide and populating the expanded cell with display content associated with a media program represented by the media program listing. Corresponding systems and methods are also described.