发明授权
- 专利标题： Salts of DPP-IV inhibitor
- 专利标题（中）： DPP-IV抑制剂的盐
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申请号： US14002541申请日： 2012-03-02
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公开(公告)号： US09108972B2公开(公告)日： 2015-08-18
- 发明人: Bipin Pandey , Mayank Ghanshyambhai Dave , Himanshu M. Kothari , Bhavin Shriprasad Shukla
- 申请人： Bipin Pandey , Mayank Ghanshyambhai Dave , Himanshu M. Kothari , Bhavin Shriprasad Shukla
- 申请人地址： IN Ahmedabad, Gujarat
- 专利权人： Cadila Healthcare Limited
- 当前专利权人： Cadila Healthcare Limited
- 当前专利权人地址： IN Ahmedabad, Gujarat
- 代理机构： Nixon & Vanderhye P.C.
- 优先权： IN590/MUM/2011 20110303; IN1948MUM/2011 20110706; IN2777/MUM/2011 20110930
- 国际申请： PCT/IN2012/000148 WO 20120302
- 国际公布： WO2012/147092 WO 20121101
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
The present invention discloses new salts of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine i.e. gentisate, adipate and trifluoro acetic acid salts. The invention also describes the new. crystalline and amorphous forms of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine gentisate. The present invention also discloses novel crystalline salt form of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride and novel crystalline and amorphous salt forms of besylate and process for their preparation and isolation.
公开/授权文献
- US20140051856A1 NOVEL SALTS OF DPP-IV INHIBITOR 公开/授权日：2014-02-20
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