Aspects of a method and system for interfacing with an electronic device via respiratory and/or tactual input are provided. In this regard, respiratory and tactual input may be utilized to interact with an electronic device via a user interface. The user interface may comprise a control region that may enable navigating and selecting objects, a fixed region that may enable display of information that may be independent of a state of, or activity in, the control region, and a content region that may enable display of information that may depend on a state of, or activity in, the control region. Accordingly, objects and/or information displayed on the electronic device may be affected and/or manipulated via tactual and respiratory input. Additionally, each region of the user interface may comprise one or more zones and a size, shape, and/or location of each region may be customized by a user.