Systems and methods are provided for dynamically allocating a memory subsystem. An exemplary embodiment comprises a method for dynamically allocating a memory subsystem in a portable computing device. The method involves fully interleaving a first portion of a memory subsystem having memory components with asymmetric memory capacities. A second remaining portion of the memory subsystem is partial interleaved according to an interleave bandwidth ratio. The first portion of the memory subsystem is allocated to one or more high-performance memory clients. The second remaining portion is allocated to one or more relatively lower-performance memory clients.