Apparatus and methods for conditional plasticity in a neural network. In one approach, conditional plasticity mechanism is configured to select alternate plasticity rules when performing connection updates. The selection mechanism is adapted based on a comparison of actual connection efficiency and target efficiency. For instance, when actual efficiency is below the target value, the STDP rule may be modulated to increase long term potentiation. Similarly, when actual efficiency is above the target value, the STDP rule may be modulated to increase long term connection depression. The conditional plasticity mechanism dynamically adjusts connection efficacy, and prevents uncontrolled increase of connection weights, thereby improving network operation when processing information of a varying nature.