发明授权
- 专利标题: Method for producing glycolic acid using an inducible promoter
- 专利标题(中): 使用诱导型启动子生产乙醇酸的方法
-
申请号: US13704578申请日: 2011-06-15
-
公开(公告)号: US09121043B2公开(公告)日: 2015-09-01
- 发明人: Wanda Dischert , Rainer Figge , Philippe Soucaille
- 申请人: Wanda Dischert , Rainer Figge , Philippe Soucaille
- 申请人地址: FR Saint Beauzire
- 专利权人: METABOLIC EXPLORER
- 当前专利权人: METABOLIC EXPLORER
- 当前专利权人地址: FR Saint Beauzire
- 代理机构: Miles & Stockbridge P.C.
- 优先权: EP10305635 20100615
- 国际申请: PCT/EP2011/059884 WO 20110615
- 国际公布: WO2011/157728 WO 20111222
- 主分类号: C12P7/42
- IPC分类号: C12P7/42 ; C12N15/70 ; C12N15/63
摘要:
The present invention relates to use of inducible promoters in the production of glycolic acid by fermentation. The present invention concerns a method for the production of glycolic acid in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, modulating in said microorganism the expression of a target gene with an external stimulus, and recovering glycolic acid from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in glycolic acid production is under the control of a heterologous inducible promoter whose activity is modulated with said external stimulus. The invention also concerned the modified microorganism used in the method of glycolic acid production.
公开/授权文献
信息查询