A geothermal power generation system using heat exchange between working fluid and molten salt includes a heat collecting unit. A plurality of molten salt containing units are disposed in the ground at predetermined intervals from each other. A heat exchanging unit transfers a heat source of the heat collecting unit to the molten salt in the plurality of molten salt containing units. A plurality of working fluid containing units respectively surround the molten salt containing units and are disposed in the ground at predetermined intervals from each other. A turbine unit is connected to the plurality of working fluid containing units, and generates mechanical energy using steam energy that is generated by the plurality of working fluid containing units. A power generating unit is connected to the turbine unit, and generates electrical energy using the mechanical energy.