The invention relates to the technical field of wireless communications, and in particular to a method, system, and device for measuring interference, so as to solve the problem in the prior art that the precision of interference measured by a terminal is low if a cell adopts a Resource Element Muting(RE MUTING) solution. The method includes: a network side device determining configuration information of a first Resource Element(RE) group performing interference measurement (501); and the network side device generating first interference notification information according to the determined configuration information of the first RE group and sending the first interference notification information to a terminal, so as to instruct the terminal to determine the first RE group according to the first interference notification information and perform the interference measurement on the determined first RE group (502). The terminal is notified to perform the interference measurement on the first RE group, so that when the RE MUTING solution is adopted, the precision of the measured interference is increased.