Invention Grant
- Patent Title: Compositions of humanized notch fusion proteins and methods of treatment
- Patent Title (中): 人源融合蛋白的组成和治疗方法
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Application No.: US12733329Application Date: 2008-08-22
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Publication No.: US09127085B2Publication Date: 2015-09-08
- Inventor: Jan Kitajewski , Carrie Shawber
- Applicant: Jan Kitajewski , Carrie Shawber
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/US2008/010045 WO 20080822
- International Announcement: WO2009/025867 WO 20090226
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61K38/00
Abstract:
This invention provides a fusion protein comprising a single peptide, an extracellular domain of human Notch receptor protein and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder.
Public/Granted literature
- US20110008342A1 COMPOSITIONS OF HUMANIZED NOTCH FUSION PROTEINS AND METHODS OF TREATMENT Public/Granted day:2011-01-13
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