Invention Grant
US09133144B2 Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
有权
1- [2-（2,4-二甲基 - 苯硫基） - 苯基] - 哌嗪的制备方法
![Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine](/docs/US/2015-09-15/US09133144B2/abs.jpg.600x600.jpg)
- Patent Title: Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
- Patent Title (中): 1- [2-（2,4-二甲基 - 苯硫基） - 苯基] - 哌嗪的制备方法
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Application No.: US14370322Application Date: 2012-12-20
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Publication No.: US09133144B2Publication Date: 2015-09-15
- Inventor: Kim Lasse Christensen
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Copenhagen-Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Copenhagen-Valby
- Agency: Fish & Richardson P.C.
- Priority: DK201200006 20120103
- International Application: PCT/EP2012/076377 WO 20121220
- International Announcement: WO2013/102573 WO 20130711
- Main IPC: C07D295/04
- IPC: C07D295/04 ; C07D295/096
![Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine](/abs-image/US/2015/09/15/US09133144B2/abs.jpg.150x150.jpg)
Abstract:
A process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine and pharmaceutically acceptable salts is disclosed that involves reacting compounds of formula II, III, IV under Pd catalysis and in presence of phosphine ligands to give Compound I.
Public/Granted literature
- US20140343287A1 Process for the Manufacture of 1-[2-(2,4-Dimethyl-Phenylsulfanyl)-Phenyl]-Piperazine Public/Granted day:2014-11-20
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